Glutathione S―Transferase (GST) is tripeptide, which plays a central role in the detoxification of electrophilic xenobiotics, including cytotoxic drugs and carcinogens, by conjugation with reduced glutathione. There are four major classes of
human
GST:
pi, alpha, mu and microsomal. They are proposed as a marker for human and experimental neoplasia including liver, kidney, lung, colon, uterine cervix, etc.
Expression of pi, alpha, mu form of GST in control (15 cases), CIN (14 cases), invasive carcinoma (28 cases) of human uterine cervix was investigated immunohistochemically. They were selected from September, 1992, to June, 1992, in the department
of
Obstetrics and Gynecology, Yonsei university College of medicine.
In nucleus, the expression of GST pi was increased statistically significant in case of CIN and invasive Ca. Of Cx. compared to control(p=0.018, p=0.002). But expression or GST alpha, mu has no significant difference in each case.
In cytoplasms, the expression of GST pi was increased statistically significant in case of CIN and invasive Ca. Of Cx. (p=0.001, p0.001). But expression of GST alpha, mu has no significant difference in each case.
There was no statistically significant difference in expression of GST isoenzymes of each nucleus and cytoplasm according to stage and cell type in Ca. of Cx.
The further evaluation of survival and expression of GST pi in Ca. of Cx. In order to establish new prognostic factor in Ca. of Cx.
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